Treatment for 7-OH, MGM-15, and other Kratom Extracts

We treat opioid withdrawal and substance use disorder in Oklahoma City, including dependence on Kratom, 7-OH, 7OHM, MGM-15, and products marketed as Kratom Alkaloids.
Private • Appointment-only • Oklahoma City
Oklahoma’s Kratom Consumer Protection Act (63 O.S. § 1-1432.4) restricts kratom products that exceed statutory 7-hydroxymitragynine limits and prohibits products containing synthesized kratom alkaloids. A 2025 amendment (SB 891, effective Nov. 1, 2025) defines compliant kratom products as those with no synthesized kratom alkaloids and 7-hydroxymitragynine ≤ 1% of total kratom alkaloids by weight, as confirmed by laboratory testing.

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​You Didn't Expect to Be Here.

​Most of our patients didn't start out looking for opioids. You likely bought a package at a local smoke shop to help with pain, energy, or anxiety. It was legal, accessible, and effective.

But since Oklahoma enforced the 1% cap on 7-Hydroxymitragynine (7-OH), the products you relied on have disappeared from shelves. Many patients are now finding that the legal Kratom replacements (like Pseudoindoxyl blends) don't work, leaving them in a state of panic and severe physical withdrawal.

If you are feeling flu-like symptoms, restless legs, severe anxiety, depression, or insomnia when you stop taking these Kratom products, you are not alone. You are experiencing Kratom opioid withdrawal, and it is a medical condition we can treat.

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​Why Quitting Feels Impossible

​You aren't weak; your brain chemistry has changed.

7-Hydroxymitragynine (7-OH) is a potent alkaloid found in Kratom extracts. Unlike natural leaf powder, these concentrated tablets act heavily on the Mu-Opioid Receptors in your brain—the exact same receptors targeted by prescription painkillers.

When you abruptly stop taking them (because the shop sold out or the law changed), your brain goes into shock. This is why "Pseudo" blends often fail—they target different receptors or cause heavy sedation without stopping the cravings.

Dr. Westcott understands this pharmacology. We don't treat this as a bad habit. We treat it as a neuro-chemical imbalance that requires medical stabilization.

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​Stop the Withdrawal. Keep Your Dignity.


​You do not need to go to a 30-day rehab or stand in line at a methadone clinic to get off Kratom Alkaloids. 

We treat dependency on Kratom Alkaloids, including 7-OH, MGM-15, and other designer drugs such as Tianeptine, using a combination of Suboxone (buprenorphine/naloxone) and other targeted medications.

  • Fast-Acting: These treatments stop withdrawals soon after your first dose.
  • Blocks Cravings: It quiets the mental obsession so you can focus on your work and family.  ​
  • Private: We are a direct-pay medical practice. No insurance records. No employers finding out. Just a doctor's appointment.​

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​We Treat Dependency On Pharmaceutical Grade Opioids—as well as Gray-Market Synthetic Opioids​

Please Note: Many gray-market opioids are sold under brand names that include descriptive labels such as Kratom Alkaloids, 7-OH, OHMS, MGM-15, Pseudo, Research Chemicals, and Florida Compliant, but the actual chemical makeup can vary dramatically from one product to the next—and even from batch to batch of the same brand. Labels and ingredient listings are often incomplete and misleading, and some products may contain different molecules, unexpected additives, or much higher potency than the customer believes. Because of this, any potency or effect described below should be understood as potential, not guaranteed for every retail product.
While some of these alkaloids can occur in Kratom leaf in trace amounts, many modern retail products contain added, concentrated, or synthesized versions (or semi-synthetic derivatives) that act like high-potency opioids. This laboratory enhancement is what drives rapid dependence and higher overdose risk compared with traditional Kratom leaf products.
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Prescription opioids (FDA-approved medications)​
  • Also Known As: Fentanyl, Hydrocodone, Oxycodone, Tramadol
  • ​Risk Level: Fatal Overdose Risk
  • We provide medication assisted treatment (MAT) for Prescription Opioids.

Illicit Opioids:
  • Also Known As: Heroin
  • Risk Level: Fatal Overdose Risk
  • We provide medication-assisted treatment (MAT) for Illicit Opioids.

Unregulated Retail Opioids
  • Also Known As: Gas Station Heroin
  • Risk Level: Fatal Overdose Risk
  • We provide medication-assisted treatment (MAT) for Unregulated Retail Opioids.
Emerging Gray Market Opioids:

7-Hydroxymitragynine (7-OH & 7-OHS)
  • Also Known As: OHS, 7Os Tabz, Legal Oxy, Sevens. 
  • Risk Level: Severe Dependency Risk.
  • Creates rapid physical dependence often mistaken for a mild herbal habit. In preclinical opioid assays, 7-OH has been reported to be ~10× as potent as morphine. Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances. (*Matsumoto K, Horie S, Ishikawa H, et al. Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. Life Sci. 2004;74(17):2143-2155. doi:10.1016/j.lfs.2003.09.054.)

1,2-Dihydro-7-Hydroxymitragynine (MGM-15)
  • Also Known As: MGM-15, "Research Powder", Dihydro, "15s", "Full Spectrum Extract". 
  • Risk Level: Severe Dependency Risk.
  • Its longer duration may increase accumulation risk, especially with repeat dosing or mixing substances. Found to be approximately *50x morphine potency in animal studies.  Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances. (*Matsumoto K, Narita M, Muramatsu N, et al. Orally active opioid μ/δ dual agonist MGM-15/MGM-16… J Pharmacol Exp Ther. 2014;348(3):383-392. doi:10.1124/jpet.113.208108.)


7-Acetoxymitragynine
  • Also Known As: Ace, Super-7, 7-Acetoxy, Acetylated Extract. 
  • Risk Level: Severe Dependency Risk.
  • Chemically modified for quick absorption, creating an intense response that accelerates addiction. Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances.


Mitragynine Pseudoindoxyl
  • Also Known As: Pseudo, Reds, The Red Pill, Nighttime Kratom. 
  • Risk Level: Highly Addictive; Heavy Sedation.
  • A rearranged 7-OH molecule that in isolated tissue assays, Mitragynine Pseudoindoxyl was reported *20× more potent than morphine. May carry higher risk of heavy sedation and respiratory depression than traditional leaf products. Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances. (Váradi A, Marrone GF, Palmer TC, et al. Mitragynine pseudoindoxyl, a potent analgesic with a unique opioid receptor profile. J Med Chem. 2016;59(18):8381–8397. doi:10.1021/acs.jmedchem.6b00748.)


Speciociliatine
  • Also Known As: Sling, Raw Leaf Extract, Full Spectrum, Specio. 
  • Risk Level: Highly Addictive; High Bioavailability.
  • A natural Kratom alkaloid now being isolated; it stays in the body longer than standard Mitragynine, increasing toxicity risks. Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances.


Mitragynine HCL
  • Also Known As: Salt Base, Nano Kratom, Fast Acting Powder. 
  • Risk Level: Highly Addictive.
  • A chemically modified salt-form of Kratom that is highly soluble, hitting the bloodstream much faster than natural plant powder. Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances.


Tianeptine Sodium
  • Also Known As: Tia, Reds, Whites, Pegs. 
  • Risk Level: Highly Addictive; Compulsive Redosing.
  • Extremely short half-life causes manic redosing behavior; withdrawal is immediate and severe.


Tianeptine Sulfate
  • Also Known As: Slow Tia, Tia, Whites, Tianeptine Sulfate. 
  • Risk Level: Severe Dependency Risk; Prolonged Withdrawal.
  • Slower onset than sodium but creates a long-lasting dependency that is difficult to taper.


Tianeptine Ethyl Ester
  • Also Known As: Tia, Tia FA, Free Acid, New Formula Reds, Tianeptine FA, Tianeptine Free Acid. 
  • Risk Level: Severe Dependency Risk.
  • A chemical variant used to skirt state bans; metabolizes into tianeptine in the liver with unpredictable potency.


Mitragynine Liquid Extract
  • Also Known As: Purple Bottles, MIT45s, Gold Shots, Liquid Extracts, SuperK, FF, Blue Bottles, Silver Caps, The Tonic, Botanical Tonics, Kava Drinks. 
  • Risk Level: Highly Addictive; Liver Toxicity & Seizures.
  • High-dose concentrated alkaloids can cause acute liver injury and seizures in healthy adults.


Beta-Phenyl-Gamma-Aminobutyric Acid
  • Also Known As: Silvers, The Grey Bottles, Chrome, Double Trouble, Silver Bullets, Walkers, Sleeps, Liquid Dawn, RD, Nootropics, Gas Station Xanax, Lift, FAA, Focus Shots, Party Shots.
  • Risk Level: Severe Dependence Risk; Dual-Dependency.
  • Causes opioid and Benzo-like withdrawal (tremors, hallucinations, delirium) that requires separate detox from opioids.


4-Fluorophenibut
  • Also Known As: F-Phenibut, Fluoribut, Focus Capsules. 
  • Risk Level: Highly Addictive; High-Potency Overdose.
  • A fluorinated derivative 5-10x stronger than Phenibut; high risk of blackout and unconsciousness.


O-Desmethyltramadol (O-DSMT)
  • Also Known As: Desmetramadol, “O-DSMT”, “Krypton” (a product found to contain O-DSMT).
  • Risk Level: High Dependence Risk; Seizures (tramadol-class) & Respiratory Depression.
  • The active metabolite of tramadol and a potent mu-opioid receptor agonist. Tramadol-class exposures have been associated with seizures, and withdrawal can include unusual sensory symptoms (e.g., numbness/tingling), especially with high doses or mixed substances.

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SR-17018 (SR-17)
  • Also known as: Research Chemical / Research Pellets.
  • Risk level: Opioid with abuse and physical dependence potential (animal studies).
  • SR-17018 is an experimental G-protein–biased μ-opioid receptor agonist. In animal studies, tolerance appears assay-dependent (reduced in some models, present in others), and physical dependence/withdrawal can occur.​


Piperidylthiambutene (PTB
  • Also known as: Piperidinohton
  • Risk Level: Severe Dependence Risk; Extreme Potency
  • A synthetic opioid from the thiambutene family described in mid-20th-century analgesic research and later observed in the modern novel-opioid market. It has shown opioid activity comparable to morphine in animal models. Because it is an opioid, it can cause dangerous respiratory depression and overdose—especially when strength and purity are unknown.


N-Desethyl Isotonitazene
  • Also Known As: ‘oxy,’ ‘M30s,’ ‘dope,’ 'Zeens', 'Zeenies', 'ISO', or 'Tony'.
  • Risk Level: Severe Dependence Risk; Extreme Potency.
  • N-desethyl isotonitazene is an emerging nitazene (benzimidazole) synthetic opioid. In laboratory receptor studies, it has been reported as ~20× more potent than fentanyl. Nitazenes have also been detected in illicit drug products including counterfeit pills and, in some reported cases, refillable vape liquids.​​

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​FAQs For Smoke Shop Customers

Note: Human clinical data on newer Kratom-derived synthetics (e.g., MGM-15) is limited; recommendations are based on known opioid-receptor pharmacology, emerging forensic reports, and perioperative experience with heavy Kratom exposure. 

​1. Do 7-Hydroxymitragynine (7-OH) or MGM-15 show up on standard employment drug tests?
No. Standard workplace immunoassay panels (e.g., 5-panel/10-panel) typically do not target kratom alkaloids. Detection usually requires targeted laboratory testing (often LC-MS/MS), and availability varies by lab and by compound.

2. Are the Energy Supplements sold at smoke shops natural Kratom?
Not always. Some products contain Kratom leaf extract, but others may contain added or concentrated alkaloids or ingredients not fully disclosed on the label. Because these products are unregulated, contents and potency can vary widely between brands—and even between batches. Products marketed as “natural” or “plant-based” may still contain lab-enhanced alkaloids or other substances that increase dependence risk.

3. Why is MGM-15 considered more dangerous than morphine?
MGM-15 is a semi-synthetic, kratom-derived opioid. Preclinical findings suggest high potency and prolonged activity relative to traditional kratom leaf preparations. Prolonged duration may increase accumulation risk with repeated dosing, particularly in polysubstance use, which can increase the likelihood of excessive sedation and respiratory depression.

4. What are "Research Chemicals" and why are they in 7-OH products?
To circumvent bans on 7-OH, manufacturers often reformulate products using "Research Chemicals". These are experimental compounds that have never been tested on humans. Consuming them carries the risk of organ failure, neurological damage, or unexpected toxic reactions because their safety profiles are completely unknown.

5. Does MGM-15 interfere with hospital-administered anesthesia and pain medication?
Yes—this is a real concern. Compounds that strongly activate μ-opioid receptors can increase opioid tolerance and alter how patients respond to pain medicines. In perioperative case reports, heavy Kratom exposure has been associated with unusually high anesthetic/analgesic requirements and difficult-to-control pain. If you are taking high-potency Kratom extracts or Kratom-derived opioids (e.g., 7-OH products or MGM-15), you should tell paramedics, ER clinicians, and anesthesiology staff. They may need to use higher opioid doses, different medications, and/or non-opioid multimodal pain strategies to control pain safely during emergencies. 

6. Does MGM-15 cause permanent damage to organs?
Because these products are unregulated, contamination and adulteration are recognized risks, including residual solvents or heavy metals depending on how a product is manufactured. High-dose exposure can also strain liver and kidney function, especially when ingredients and potency are unknown. Severe adverse events have been reported with some unregulated products, particularly when mixed with other substances.

7. Why are withdrawals from MGM-15 and 7-OH so difficult to manage?
MGM-15 is believed to bind to multiple opioid receptors simultaneously (unlike some traditional opiates that target just one). This dirty binding creates a complex dependency that results in debilitating withdrawal syndromes. Patients often report that the physical and psychological crash is far more severe than withdrawal from prescription painkillers or Heroin.

8. Why don't standard detox kits work for 7-OH addiction?
Standard at-home detox kits or generic rehab protocols fail because they are designed for short-acting opiates. Because unregulated synthetic opioids use unknown chemical formulas with varying half-lives, they require a specialized medical stabilization protocol. Generic detox methods often precipitate immediate, severe withdrawal seizures or intolerable pain.

9. How addictive are the Energy Boosters containing 7-OH?
Extremely. Products containing concentrated 7-OH or MGM-15 can be up to 50 times more potent than morphine. Users often develop a physical dependency within just a few days of consecutive use. The brain’s reward system is hijacked so aggressively that users feel unable to function, work, or get out of bed without the substance.

10. Is there a medical treatment for MGM-15 dependency?
Yes. While difficult to treat, dependency can be managed through Medication-Assisted Treatment (MAT). At Medical Therapy Associates, we utilize advanced stabilization protocols that bypass the blocking effect of these synthetics, allowing patients to normalize their brain chemistry without suffering through the debilitating withdrawal symptoms associated with cold turkey quitting.

11. Can I just taper off 7-OH products on my own?
Tapering is dangerous due to the inconsistent dosing in these unregulated products. One shot or gummy might contain 15mg of active ingredients, while the next contains 50mg, making a controlled taper impossible. Medical supervision is recommended to avoid accidental overdose during the tapering attempt.

12. Can taking 7-OH or MGM-15 cause seizures?
Yes. Seizures have been reported in association with Kratom use, particularly with concentrated extracts, high doses, or mixing with other substances.

13. What does MGM-15 do to mental health?
Beyond addiction, these synthetic opioids can induce acute psychosis, paranoia, and severe anxiety (panic) attacks. Long-term use often leads to anhedonia, a condition where the user creates a chemical imbalance that makes them physically incapable of feeling joy or happiness without the drug.

14. Does 7-OH affect testosterone or hormones?
Chronic use of opioids is linked to hormonal suppression. In men, this often manifests as critically low testosterone levels, fatigue, and muscle loss. In women, it can cause amenorrhea (loss of menstrual cycle) and hair loss.

15. Is it safe to mix these supplements with alcohol or antidepressants?
Absolutely not. Mixing 7-OH or MGM-15 with alcohol or SSRIs (antidepressants) can depress the central nervous system resulting in hypoxia, where a user stops breathing in their sleep and never wakes up.

​16. I only take Kratom/7-OH. Is Suboxone (Buprenorphine) too strong for me?
​Not necessarily. Many concentrated 7-OH tablets are significantly more potent than morphine. If you are taking multiple doses a day, your tolerance is likely high enough that cold turkey would be dangerous or unbearable. Dr. Westcott tailors the Suboxone dose to your specific tolerance—often using lower doses for Kratom patients than for Fentanyl patients—to ensure a comfortable, safe taper.

​17. Will my family or job find out if I start treatment at Medical Therapy Associates?
No. To protect your professional and personal reputation, we operate on a strict direct-pay model ($150 per month). We do not accept insurance, meaning your diagnosis and treatment history are never reported to insurance databases or employers. Your care is protected by HIPAA and remains strictly between you and Dr. Westcott.

18. If I take Suboxone (or Buprenorphine), can I work without restriction?
​Yes. In fact, that is the goal. Unlike inpatient rehab, our outpatient medical model allows you to get your medication, stabilize your symptoms, and go right back to work the same day. You should feel normal, not sedated. Patients on medication-assisted treatment live normal lives without the severe cravings to get high.

​19. What is the Cost?
​Your first office visit will cost $200 as a new patient. Future office visits for established patients are $150 per month. To keep our overhead and pricing as low as possible, we do not accept insurance. Payment methods include cash, debit, and credit cards.

20. Is the cost of my medication included in the office visit cost?
No. The $150 monthly fee covers your medical consultation, evaluation, and the management of your treatment plan by Dr. Westcott. You will pay for the medication itself separately at the pharmacy of your choice.
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Important Note on Insurance: Even though our office does not accept insurance for the visit, you can typically use your health insurance to pay for the medication at the pharmacy. If you do not have insurance, we recommend using discount cards like GoodRx or Optum Perks for significant discounts to the cost of generic prescriptions.


​We're Here to Help


​Don't let an addiction, or a legislative ban, ruin your life.

​You have options other than the smoke shop. Get professional medical help from the doctor trusted to treat other physicians.

    Contact Us Today
    Learn how Medication-Assisted Treatment     can help!

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​Location & Hours

Address

​Medical Therapy Associates
​3700 N Classen Blvd, #200
Oklahoma City, OK 73118

Hours: By appointment Only

Phone: (405) 840-4800

Service Area

Oklahoma City, Edmond, Deer Creek, Enid, Ponca City, Tulsa, Ardmore, Paul's Valley, Fairview, Elk City, Norman, Weatherford, Jenks, Sand Springs, Moore, Piedmont, Yukon, Midwest City, Del City, Bethany, Mustang, Tuttle, Newcastle, Noble, Jones, Chandler, Choctaw, Shawnee, Warr Acres, The Village, Nichols Hills, El Reno, Blanchard, Spencer, Bethany, Luther, and Guthrie.

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​Crisis Resources

​If you are experiencing a mental health emergency, call 988 in Oklahoma. For medical emergencies, dial 911. 
​Medical Disclaimer: The content provided on this website is for informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. Use of this website does not establish a doctor-patient relationship with Medical Therapy Associates or Dr. Robert Westcott. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. ​All medication management and prescriptions are authorized solely at the discretion of Medical Therapy physicians and based on individual and in-person medical assessment. Terms and conditions apply to treatment at Medical Therapy Associates.

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Trademark Non-Affiliation Notice Medical Therapy Associates is an independent medical practice specializing in addiction medicine and toxicology. We are not affiliated with, associated with, authorized by, endorsed by, or in any way officially connected with any manufacturers, distributors, or owners of the commercial products mentioned on this website,

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Public Interest & Consumer Alert References to these products constitute a Consumer Safety Alert regarding matters of significant public concern. Medical Therapy Associates asserts no claim of ownership over any third-party trademarks. All trademarks, service marks, and company names remain the property of their respective owners. The information provided herein is based on clinical data, toxicology reports, and patient intake history, and is protected speech regarding public health and safety.